Newsgroup sci.research 12622

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Erin Nichols wrote:
> 
> Hello,
> I'm not exactly sure if I'm in the right place for this...
> 
I reply:
Depending on what you're after, I ran across an article in one of the 
dozen or so boxes of papers piled up in my office that may give you 
everything you want and more.  It is 'Rational Basis and New Methods for 
Proportional Limit, Machine Stiffness, Critical Stress Intensity, and 
Crack Velocity Measurements' in *Recent Developments in Mechanical 
Testing*, ASTM STP 608, ASTM (1976) pp. 20-44 by R. B. Clough (NBS - now 
NIST).  
Although dated, the material still seems relevant.
Mark Friesel

george blahusiak  wrote in article
<5anekj$d3c@news.mel.aone.net.au>...
> meron@cars3.uchicago.edu wrote:
> >2)  The government is under no obligation to base its decisions on 
> >scientific considerations.  There is no place in the Constitution 
> >where it says "The government shall not enact a law without the 
> >advice and consent of the scientific community".  The government is a 
> >political body and has the right to ignore any scientific 
> >recommendation and consideration if it choses so (whether it is smart, 
> >that's another story).
> 
> Really?!?!?!
> 
> I always thought the purpose of govt was the benefit of the governed.
> And you say you are writing from uchicago? Surely you jest.
> 
> Second, the first principle of good decision making, and I think I
> should include the govt here, is to GET THE FACTS. It is a
> fundamental, like life liberty, and the pursuit of happiness, which,
> if memory serves me, appears somewhere else as well. If you have to
> spell it out using words of less than 5 letters you have missed the
> point.
> 
> Perhaps one might suggest a reading of Aristotle's Ethics. That goes
> for any scientist, not to mention everyone else.
Obviously, whether you agree with the government's position in this case or
not, they do believe they are acting to the benefit of the governed.  That
is, unless you can come up with some conspiracy theory that better explains
the laws in question.  
Like it or not, (s)he's right about science and the law--there is no
absolute connection between them.  Remember, the Constitution was written
at a time when there were other, more powerful beliefs than faith in
natural law.  Religion and superstition were *far* more powerful than their
belief in natural law.  Ever heard of the Salem Witch Trials?  
I happen to be a scientist, and I personally believe in the fundamental
truth of science, but I also realize that it is probably arrogant of
Science to claim to be "THE FACTS", as you put it.   One of the most
important founding principles of the United States was freedom of religion,
and the fundamental right of every one (including those that participate in
the government) to believe in whatever structure of truth they see fit. 
There is no way that you can prove that science or logic are the best
possible representations of the universe, without resorting to science or
logic in the proof.  In other words, Science *is* in fact a religion. 
Granted, people that believe in science happen to feel that it is a more
accurate representation of the world than any other set of beliefs.  But
that is not unique to science--all religions are that way.  
One might expect the government to act upon scientifically established
facts if the will of the governed says it should be so.  However, with
Science suffering such a bad name in this country these days, that's not
such a certain proposition.
Having said that, I agree with both of you that it is foolish not to base
legislative decisions on scientifically established facts.  But you do have
to admit that that is a biased opinion, in that it is coming from someone
that believes in the truth of science.
	Eric Lucas

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                                Department of Molecular Biology and Genetics
                                Johns Hopkins University School of Medicine
                                Ross Research Bldg., Rm. 1050
                                720 N. Rutland Ave.
                                Baltimore, MD 21205
January 5th, 1997
To whom it may concern:
I am writing in regards to potential post-doctoral / entry level positions
that may be available in the areas of basic science AIDS research and HIV
vaccine development.
I am a 5th year Ph.D. candidate in the Biochemistry, Cellular and Molecular
Biology Training Program at the Johns Hopkins University School of Medicine.  I
plan to complete my graduate program in the spring/summer of 1997.
My research, under the direction of Robert F. Siliciano M.D. Ph.D., has been
focused in two areas related to HIV/AIDS research.  I developed a novel method
(AIDS Research and Human Retroviruses, 10: 1423, 1994) for the detection
and evaluation of cytolytic T-cell responses to candidate AIDS vaccines
being tested
in Phase I clinical trials at the Center for Immunization Research here at 
Johns Hopkins (J. Infect. Dis. 171: 1623, 1995).  This method is now widely
used in the testing of AIDS vaccines.  
More recently my thesis work has focused on developing a better understanding
of the role of a highly conserved YXXL internalization motif within the
envelope glycoprotein gp41 of HIV-1 in viral assembly, host immune recognition,
and CD4 cell loss (J. Virol., 10:6547-6556 (1996)). 
I seek a post doctoral / entry level position in the area of basic
sciences AIDS research and HIV vaccine development. My nine years research
experience, my excellent writing and verbal skills, along with my proven
ability to publish in peer reviewed journals makes me an excellent
candidate.   
I welcome an opportunity to discuss my capabilities with respect to
opportunities that may exist in this area.  I have enclosed a copy of my
curriculum vitae along with the name and addresses of three references for
your information.  
Please feel free to contact me by mail at the above address or by telephone or
E-mail:
        Phone: 410-955-7757
        Fax: 410-955-0964
        email: egan@welchlink.welch.jhu.edu
   http://www.welch.jhu.edu/~egan
Sincerely,
Michael A. Egan
---------------------------------------------------------------------------
                                CURRICULUM VITAE
Name:                           Michael A. Egan
Current Appointment:            Ph.D. Candidate, Graduate Program in    
                                Biochemistry, Cellular and Molecular Biology,   
                                Johns Hopkins University, School of
Medicine,                                           
                                Baltimore, MD
Office Address:                 Johns Hopkins University School of Medicine,
                                Department of Medicine
                                Rm. 1050 Ross Research Bldg.
                                720 N. Rutland Ave.
                                Baltimore, MD 21205
                                Phone: 410-955-7757
                                Fax: 410-955-0964
                                e-mail: egan@welchlink.welch.jhu.edu
                                http://www.welch.jhu.edu/~egan
Home Address:                   3721 Rexmere Rd.
                                Baltimore, MD 21218
                                Phone 410-366-3268
EDUCATION
1992-present                    Ph.D. Candidate, Graduate Program in    
                                Biochemistry, Cellular and Molecular Biology    
                                (BCMB), Johns Hopkins University, School of     
                                Medicine, Baltimore, MD
1987-1992                       B.S., Chemistry, Magna Cum Laude, 
                                Northern Arizona University, Flagstaff, AZ
                            HONORS AND AWARDS
Undergraduate                   Magna Cum Laude in Chemistry
Education                       Grade Point Average 3.80/4.00
                                NSF Summer Research Fellowship
                                Golden Key National Honor Society
                                Phi Lambda Upsilon Chemistry Honor Society
                                Phi Kappa Phi Honor Society
                                Dean's List seven semesters
Post Graduate                   Fellowship, Graduate Program in Biochemistry,   
Education                       Cellular and Molecular Biology (BCMB), Johns 
                                Hopkins University School of Medicine
                                WORK EXPERIENCE
1988-1991                       Undergraduate Chemistry lab teaching assistant,
                                Northern Arizona University
Summer 1991                     NSF Research Fellowship, University of Georgia
1983-1987                       Enlistment in the U.S. Marine Corps, honorable 
                                discharge.
                           RESEARCH EXPERIENCE
1992-Present                    Elucidating the role of the YXXL
internalization 
                                motif within the envelope protein (gp41) of 
                                HIV-1 in viral assembly, immune
recognition, and 
                                CD4 cell loss.  Developed a novel method,
now                                   
                                widely used in the AIDS field, for the
detection        
                                of (HIV-1)-specific CTL responses in human 
                                vaccine recipients. In a Phase I
clinical                                        
                                trial evaluated the ability of an experimental 
                                HIV-1 vaccine to elicit HIV-specific CTL 
                                responses in sero-negative volunteers.
                                Laboratory of Robert F. Siliciano, 
                                Department of Medicine,
                                Johns Hopkins University School of Medicine.
1991-1992                       Using semi-empirical computational methods to 
                                calculate the structure and electronic 
                                properties of the mono-boro-analogs of 
                                acetylcholine. 
                                Laboratory of Dr. Robert W. Zoellner, 
                                Department of  Chemistry, 
                                Northern Arizona University
NSF 1991 Summer                 Mutagenesis of murine ferrochelatase in looking 
Fellowship                      for molecular mimicry in erythropoietic 
                                protoporphyria.
                                Laboratory of Dr. Harry A. Dailey, Department of
                                Microbiology, University of Georgia
1988-1992                       The effect of endurance training on glucose 
                                metabolism.
                                Laboratory of Dr. Scott Savage and Dr.
Hans M.          
                                Gunderson, Exercise Physiology Lab, Northern 
                                Arizona University
SKILLS
Trained in standard molecular biology techniques, PCR, SDS-PAGE, Western
Blot, Pulse Chase Analysis, the use of Fluorescence Activated Cell Sorter
analysis (FACS), all aspects of human tissue culture, and optimization and
implementation of standard immunological assays (Cr51 release, CTL assays,
ADCC, ELISA). Five years experience in the handling and use of high titer
infectious material (HIV-1, vaccinia virus, EBV) under Biohazard Level 3
(P3) laboratory conditions. Computer trained with experience programming
in FORTRAN, C/C++, HTML. Skilled in the use of DOS/Windows, Mac and Unix
operating systems. Able to efficiently access and publish information on
the WWW and Internet. 
PUBLICATIONS
1. Michael A. Egan and Robert W. Zoellner.  Structural and Electronic
Characteristics of the Monoboro-Analogs of the Acetylcholine Cation As
Determined by the Semiempirical MNDO Computational Method.  J. Org. Chem.,
58:1719-1729 (1993).
2. M.N. Lubaki, Michael. A. Egan, Robert. F. Siliciano, Kent. J. Wienhold,
and Robert. C. Bollinger. A Novel Method for the Detection and Expansion
of HIV Type 1-Specific Cytolytic T Lymphocytes. AIDS Res. Hum.
Retroviruses, 10:1423-1427 (1994).
3. Michael A. Egan, Wendy A. Pavlat, James Tartaglia, Enzo Paoletti, K. J.
Wienhold, Mary Lou Clements, and Robert F. Siliciano. Induction of Human
Immunodeficiency Virus Type 1 (HIV-1)-Specific Cytolytic T Lymphocyte
Responses in Seronegative Adults by a Nonreplicating,
Host-Range-Restricted Canarypox Vector (ALVAC) Carrying the HIV-1MN env
Gene, J. Infect. Dis., 171:1623-1627 (1995).
4. Robert. C. Bollinger, Michael. A. Egan, Tae-Wook Chun, Bonnie
Mathieson, and Robert F. Siliciano. Cellular Immune Responses to HIV-1 in
Progressive and Non-Progressive Infections. AIDS, 10:1-12 (1996).
5. Michael A. Egan, Lucy M. Carruth, Jennifer F. Rowell, Xiaofang Yu, and
Robert F. Siliciano. HIV-1 Envelope Protein Endocytosis Mediated by a
Highly Conserved Intrinsic Internalization Signal in the Cytoplasmic
Domain of gp41 Is Suppressed in the Presence of the Pr55gag Precursor
Protein, J. Virol., 70:6547-6556 (1996).
Abstracts
1. Michael A. Egan and Robert W. Zoellner.  The Mono-Boro-Analogs of
Acetylcholine: Structural and Electronic Comparisons to the Parent
Acetylcholine Using the MNDO Computational Method.  Annual American
Chemical Society Meeting, San Francisco, CA, April 1992.
2. Michael A. Egan, Kent Weinhold, Enzo Paoletti, James Tartaglia, Mary
Lou Clements, Wendy Pavlat, and Robert F. Siliciano.  Cytotoxic T
Lymphocyte Responses to Recombinant Canarypox-gp160 MN (ALVAC vCP125,
HIV-1 gp160 MN) in HIV-1 Uninfected Adult Volunteers. The 6th Annual
Conference on Advances in AIDS Vaccine Development, Alexandria, VA, 
October 30th - November 4th, 1993.
3. Michael A. Egan, Wendy Pavlat, James Tartaglia, Enzo Paoletti, Robert
F. Siliciano and Mary Lou Clements.  Induction of HIV-1-specific Cytotoxic
T Lymphocyte Responses in Seronegative Adults by a Non-Replicating, Host
Range Restricted Recombinant Canarypox Vector
Carrying the HIV-1 env Gene.  The 7th Annual Conference on Advances in
AIDS Vaccine Development, Reston VA, November 6th-10th, 1994.
4. Michael A. Egan, Wedy Pavlat, James Tartaglia, Enzo Paoletti,  Mary Lou
Clements and Robert F. Siliciano.  Cytotoxic T Lymphocyte Responses to
Recombinant Canarypox-gp160 MN (ALVAC vCP125, HIV-1 gp160 MN) in HIV-1
Uninfected Adult Volunteers.  The Frank B. Polk Symposium on AIDS,
Baltimore, MD, April 15th-16th, 1994.
5. Michael A. Egan, Jennifer F. Rowell, Robert F. Siliciano and Lucy M.
Carruth. The Role of the gp41 (YXXL) Internalization Motif in HIV-1
Assembly.", Third Conference on Retroviruses and Opportunistic Infections,
Washington, DC, January 28th - February 2nd, 1996. 
REFERENCES
                        Robert F. Siliciano, M.D., Ph.D.
                        Assistant Professor, Department of Immunology
                        Johns Hopkins University School of Medicine
                        Rm. 1049, Ross Research Bldg.
                        720 N. Rutland Ave.
                        Baltimore, MD  21205
                        Office: 410-955-2958
                        Fax:    410-955-0964
                        e-mail: rsilicia@welchlink.welch.jhu.edu
                        Robert C. Bollinger, M.D., M.P.H.
                        Assistant Professor, Division of Infectious Disease
                        Johns Hopkins University School of Medicine
                        Rm. 1159, Ross Research Bldg.
                        720 N. Rutland Ave.
                        Baltimore, MD  21205
                        Office: 410-614-0936
                        Fax:    410-955-7889
                        e-mail: rcb@welchlink.welch.jhu.edu
                        Xiao-Fang Yu, M.D., Ph.D.
                        Department of Molecular Biology and Immunology
                        Johns Hopkins University
                        School of Hygiene and Public Health
                        615 N. Wolfe, St.
                        Baltimore, MD 21205
                        Phone:  410-955-3768
                        Fax:    410-955-0105
-----------------------------------------------------------------------------
-- 
Michael A. Egan
Department of Molecular Biology and Genetics
Ross Research Bldg., Rm. 1050
Johns Hopkins University
720 N. Rutland Ave.
Baltimore MD 21205
Phone: 410-955-7757
Fax: 410-955-0964
email: egan@welchlink.welch.jhu.edu
http://www.welch.jhu.edu/~egan

In article <01bbfc2c$7def0e80$fdac11cf@lucasea-home>, "Eric Lucas"  writes:
>
>
>Superdave the Wonderchemist  wrote in article
>> 
>> Might I pose a few questions to provoke thought on opposing sides of 
>> the issue?
>> 
>> 1)  Is it not illegal under the Consitution for the federal government to
>
>> meddle into a state's business if it is not specifically spelled out in 
>> the US Constitution?  Or does Slick Willie think he can bend the 
>> interstate commerce clause to fit this one?
>
>In principle, yes.  However, it is naive to think that that Article of the
>Constitution actually means anything.  The Feds have been doing this for at
>least 20 years (and probably much longer.)  They use Federal aid to the
>states to blackmail the states into doing what they want.  Examples:  the
>55 mph speed limit (states blackmailed with federal highway funds),
>seat-belt laws (blackmailed with federal highway funds, among other
>things), the 21 year drinking age (blackmailed with, among other things,
>federal highway and education aid).  All of these are examples of *state*
>laws that were, de facto, forced on the states by an overzealous Federal
>government.  The list of eggregious violations of the letter and spirit of
>the Constitution goes on and on and on and on.  And don't think it's just
>Slick Willie and his cronies.  Most of these things were enacted during
>Republican administrations (although granted the Liberals controlled
>Congress.)
Certainly.  But it goes back way further than this.  What we view is 
the age old process where during times of crisis power is (out of 
necessity) concentrated in the hands of a central government which 
then continues to hold to the power after the emergency is over.  In 
the States the process began during the Civil War, accelerated during 
the depression and went into a real high gear during WWII.  The Cold 
Wa helped to keep it going afterwards.
Now, of course, once the emergency is over, people may start 
questioning the need for having all this power in the hands of the 
government.  To prevent it, governments use one or more of the 
following techniques:
1)  Create a new emergency, like start a war with some neighbor.  This 
is not popular anymore since wars got to be very costly.
2)  Invent an emergency and start an action against it, something in 
the style of "War on (substitute your favorite subject here)"
3)  Create a mass dependence of the citizens on the government through 
the introduction of seemingly benevolent programs.  Given enough time 
people get used to rely on these programs to the point where they 
cannot imagine to themself living without them.  Then they'll support 
and defend the government's hold on power.
They really should teach kids more history in schools.  All these 
things happened many times already.
Mati Meron			| "When you argue with a fool,
meron@cars.uchicago.edu		|  chances are he is doing just the same"

Superdave the Wonderchemist  wrote in article
<5arpl0$e38@daily-planet.nodak.edu>...
> 
> : Government still says to doctor: We deny you legal permission to 
> : conduct your study
> 
> 
> Might I pose a few questions to provoke thought on opposing sides of 
> the issue?
> 
> 1)  Is it not illegal under the Consitution for the federal government to
> meddle into a state's business if it is not specifically spelled out in 
> the US Constitution?  Or does Slick Willie think he can bend the 
> interstate commerce clause to fit this one?
In principle, yes.  However, it is naive to think that that Article of the
Constitution actually means anything.  The Feds have been doing this for at
least 20 years (and probably much longer.)  They use Federal aid to the
states to blackmail the states into doing what they want.  Examples:  the
55 mph speed limit (states blackmailed with federal highway funds),
seat-belt laws (blackmailed with federal highway funds, among other
things), the 21 year drinking age (blackmailed with, among other things,
federal highway and education aid).  All of these are examples of *state*
laws that were, de facto, forced on the states by an overzealous Federal
government.  The list of eggregious violations of the letter and spirit of
the Constitution goes on and on and on and on.  And don't think it's just
Slick Willie and his cronies.  Most of these things were enacted during
Republican administrations (although granted the Liberals controlled
Congress.)
	Eric Lucas

In article <01bbfc31$671447c0$fdac11cf@lucasea-home>, "Eric Lucas"  writes:
>
>
>Coop  wrote in article
>...
>> In article <32CE071D.7FB3@vasilisa.com>, violette@vasilisa.com wrote:
>> >Another defense of science from a non-scientist while scientific
>> >organizations all over America sit quietly on their hands:
>> >
>> >From the NORML news of Jan.2, 1997, at http://www.norml.org/
>> >BIG SNIP
>> >Can a President get away with saying "You have not done enough research"
>
>> >AND "You are not allowed to do any research" at the same time to the
>> >same public?
>>         
>>         Of course he can, he's a politician not a scientist!  What did
>you 
>> expect?  Politicians pick the studies that back up their policy and
>discard 
>> the rest.  This is nothing new.  I don't condone it, but until we see
>someone 
>> truly intelligent and courageous in public office it will continue.  
>
>And this of course depends on the intelligence of the electorate,
>unfortunately....
Democracy is a very just system.  People get the government they 
deserve :-)
Mati Meron			| "When you argue with a fool,
meron@cars.uchicago.edu		|  chances are he is doing just the same"

The Logic Team and Functional Analysis Team of the University of 
Mons-Hainaut (Belgium) will organize an international meeting
about Analysis and Logic on August 24-29 1997.
You may find the first announcement on
http://sun1.umh.ac.be/~boffa/analog.htm
Arnaud Maes
maesa@sun1.umh.ac.be

In article <5aroh5$4kq@mozo.cc.purdue.edu>,
pistol@materials.ecn.purdue.edu (Peter C Tortorici) wrote:
> 
> I totally agree with this previous statement. One guy in our department
got about 4-5 offers in one month of searching, and he has one summer of
experience. The job market is very good right now, and from what I hear,
will be for the next few years.
> 
> My own $.02: There are plenty of jobs out there. Maybe it's your job search
> technique that needs to be examined.
> 
> Pete
Actually, the market depends upon what degree level you have, the field of
chemistry, techniques ( if analytical), number of years of experience and
what industrial field (pharmaceuticals, polymers, petroleum, food, etc.)
that you are exploring. 
In my search, I found that having a Ph.D. is poor right now unless you
have pharmaceutical experience. In many other areas, many companies are
trying to use MS or BS level chemists in the same positions as the
previously used Ph.D. because of lower salaries. They are moving away from
R & D and new products to "lets make money and with the stuff we have now
and develop new markets". In this case they need more engineers to keep
the plants running and a few chemists to help with problems that may arise
or develop new applications. 
Also,did the person that got 4-5 offers in one month of searching were
these positions as chemists where you lead a project or as a technician
where you follow the orders/recommendations of the chemist? [I mean no
disrepect to technicians you contribute a lot of experience and knowledge
to the labs and make chemist jobs easier, but I am just trying to gather
information]
Mike

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